B-054 Potential of Autotaxin in the Early Diagnosis of Sinusoidal Obstruction Syndrome after Allogeneic Hematopoietic Cell Transplantation

Abstract Background Sinusoidal obstruction syndrome (SOS) is a life-threatening complication after allogeneic hematopoietic cell transplantation (allo-HCT). Early intervention leads to good prognosis, but it often difficult differentiate SOS from other hepatobiliary complications. Liver biopsy the gold standard for diagnosing SOS, perform invasive testing early in transplant process, and no specific biomarker has been established. Autotaxin (ATX) useful as liver fibrosis marker, serum levels of which are elevated by metabolic inhibition sinusoidal endothelial cells. Considering pathophysiology begins with injury cells, ATX may be onset SOS. Methods A retrospective study was conducted 247 patients who had received allo-HCT, including 11 developed met EBMT criteria (male, 7; female, 4). Of 9 pathologically proven The median time allo-HCT diagnosis 31 days (range, 8–141 [male], 16–31 [female]). This cohort included 39 complications without (total bilirubin > 2 mg/dL; male, 23; 16). Serum were measured stored samples before conditioning at 1, 3, 5, 7, 14, 28, 60, 90, 180, 365 two-site enzyme immunoassay an AIA-2000 analyzer. area under receiver operating characteristic (AUROC) analyzed. Results We first investigated variability during period. fluctuated follows: decreased on day increased peaked 7–14, then again 28–60. variety factors associated such regimen administration steroids affected levels. tended higher In male patients, AUROCs 3 0.75 (in all patients; 95% confidence interval [95%CI], 0.49–1.00) complications; 95%CI, 0.48–1.00). female 14 0.88 0.77–0.98) 0.94 0.82–1.00). These findings indicated that diagnostic capacity. addition, focusing severe cases, three six above upper reference limit (a total 18 exceeded this cohort). remaining two post-transplant near or prior Conclusion Although validation further studies larger numbers cases needed, level allo-HCT.